Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials
Identifieur interne : 000A42 ( Main/Exploration ); précédent : 000A41; suivant : 000A43Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials
Auteurs : Martin Koenighofer [Autriche] ; Thomas Lion [Autriche] ; Angelika Bodenteich [Autriche] ; Eva Prieschl-Grassauer [Autriche] ; Andreas Grassauer [Autriche] ; Hermann Unger [Autriche] ; Christian A. Mueller [Autriche] ; Tamás Fazekas [Autriche]Source :
- Multidisciplinary Respiratory Medicine [ 1828-695X ] ; 2014.
Abstract
Clinical trials applying iota-carrageenan nasal spray have previously shown to reduce duration of virus-confirmed common cold. The present study pooled data of two similar clinical trials to provide further evidence for the antiviral effectiveness of carrageenan.
Individual patient data were analyzed from two randomized double blind placebo controlled trials assessing the therapeutic effectiveness of carrageenan nasal spray in acute common cold. Patients with virus-confirmed common cold (n = 254, verum 126, placebo 128) were included and the following parameters were appraised: duration of disease, number of patients with relapses, number of respiratory viruses and viral titers at inclusion (visit 1) compared to days 3–5 (visit 2).
Carrageenan treated patients showed a significant reduction in duration of disease of almost 2 days (p < 0.05) as well as significantly fewer relapses during 21 days of observation period (p < 0.05). The virus clearance between visit 1 and visit 2 was significantly more pronounced in the carrageenan group (p < 0.05). In both studies, virus-confirmed common cold was caused by three main virus subtypes: human rhinovirus (46%), human coronavirus (25%) and influenza A (14%) virus. Carrageenan nasal spray showed significant antiviral efficacy in all three virus subgroups, the highest effectiveness was observed in human corona virus-infected patients. The reduced duration of disease was 3 days (p < 0.01) and the number of relapses was three times less (p < 0.01) in carrageenan treated corona-virus-infected patients compared to control patients.
Administration of carrageenan nasal spray in children as well as in adults suffering from virus-confirmed common cold reduced duration of disease, increased viral clearance and reduced relapses of symptoms. Carrageenan nasal spray appeared as an effective treatment of common cold in children and adults.
Pooled data from
Url:
DOI: 10.1186/2049-6958-9-57
PubMed: 25411637
PubMed Central: 4236476
Affiliations:
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Martin" uniqKey="Koenighofer M" first="Martin" last="Koenighofer">Martin Koenighofer</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Lion, Thomas" sort="Lion, Thomas" uniqKey="Lion T" first="Thomas" last="Lion">Thomas Lion</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Children’s Cancer Research Institute and Lab DiaLabordiagnostik, Zimmermannplatz 8, 1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Children’s Cancer Research Institute and Lab DiaLabordiagnostik, 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id="Aff4">Marinomed Biotechnologie GmbH, Veterinaerplatz 1, 1210 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Marinomed Biotechnologie GmbH, Veterinaerplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Grassauer, Andreas" sort="Grassauer, Andreas" uniqKey="Grassauer A" first="Andreas" last="Grassauer">Andreas Grassauer</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Marinomed Biotechnologie GmbH, Veterinaerplatz 1, 1210 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Marinomed Biotechnologie GmbH, Veterinaerplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Unger, Hermann" sort="Unger, Hermann" uniqKey="Unger H" first="Hermann" last="Unger">Hermann Unger</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Laboratory of Tropical Veterinary Medicine, Veterinary University Vienna, Veterinaerplatz 1, 1210 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Laboratory of Tropical Veterinary Medicine, Veterinary University Vienna, Veterinaerplatz 1, 1210 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Mueller, Christian A" sort="Mueller, Christian A" uniqKey="Mueller C" first="Christian A" last="Mueller">Christian A. Mueller</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Fazekas, Tamas" sort="Fazekas, Tamas" uniqKey="Fazekas T" first="Tamás" last="Fazekas">Tamás Fazekas</name><affiliation wicri:level="3"><nlm:aff id="Aff1">St. Anna Children’s Hospital, Kinderspitalgasse 6, 1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>St. Anna Children’s Hospital, Kinderspitalgasse 6, 1090 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author></analytic><series><title level="j">Multidisciplinary Respiratory Medicine</title><idno type="ISSN">1828-695X</idno><idno type="eISSN">2049-6958</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Clinical trials applying iota-carrageenan nasal spray have previously shown to reduce duration of virus-confirmed common cold. The present study pooled data of two similar clinical trials to provide further evidence for the antiviral effectiveness of carrageenan.</p></sec><sec><title>Methods</title><p>Individual patient data were analyzed from two randomized double blind placebo controlled trials assessing the therapeutic effectiveness of carrageenan nasal spray in acute common cold. Patients with virus-confirmed common cold (n = 254, verum 126, placebo 128) were included and the following parameters were appraised: duration of disease, number of patients with relapses, number of respiratory viruses and viral titers at inclusion (visit 1) compared to days 3–5 (visit 2).</p></sec><sec><title>Results</title><p>Carrageenan treated patients showed a significant reduction in duration of disease of almost 2 days (p < 0.05) as well as significantly fewer relapses during 21 days of observation period (p < 0.05). The virus clearance between visit 1 and visit 2 was significantly more pronounced in the carrageenan group (p < 0.05). In both studies, virus-confirmed common cold was caused by three main virus subtypes: human rhinovirus (46%), human coronavirus (25%) and influenza A (14%) virus. Carrageenan nasal spray showed significant antiviral efficacy in all three virus subgroups, the highest effectiveness was observed in human corona virus-infected patients. The reduced duration of disease was 3 days (p < 0.01) and the number of relapses was three times less (p < 0.01) in carrageenan treated corona-virus-infected patients compared to control patients.</p></sec><sec><title>Conclusions</title><p>Administration of carrageenan nasal spray in children as well as in adults suffering from virus-confirmed common cold reduced duration of disease, increased viral clearance and reduced relapses of symptoms. Carrageenan nasal spray appeared as an effective treatment of common cold in children and adults.</p></sec><sec><title>Trial registration</title><p>Pooled data from <ext-link ext-link-type="uri" xlink:href="http://www.controlled-trials.com/ISRCTN52519535">ISRCTN52519535</ext-link> and <ext-link ext-link-type="uri" xlink:href="http://www.controlled-trials.com/ISRCTN80148028">ISRCTN80148028</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Goldmann, Da" uniqKey="Goldmann D">DA Goldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name></author><author><name sortKey="Fendrick, Am" uniqKey="Fendrick A">AM Fendrick</name></author><author><name sortKey="Sarnes, Mw" uniqKey="Sarnes M">MW Sarnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name></author><author><name 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uniqKey="Jackson G">GG Jackson</name></author><author><name sortKey="Dowling, Hf" uniqKey="Dowling H">HF Dowling</name></author><author><name sortKey="Spiesman, Ig" uniqKey="Spiesman I">IG Spiesman</name></author><author><name sortKey="Boand, Av" uniqKey="Boand A">AV Boand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garibaldi, Ra" uniqKey="Garibaldi R">RA Garibaldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bertino, Js" uniqKey="Bertino J">JS Bertino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, Jp" uniqKey="Fox J">JP Fox</name></author><author><name sortKey="Hall, Ce" uniqKey="Hall C">CE Hall</name></author><author><name sortKey="Cooney, Mk" uniqKey="Cooney M">MK Cooney</name></author><author><name sortKey="Luce, Re" uniqKey="Luce R">RE Luce</name></author><author><name sortKey="Kronmal, Ra" uniqKey="Kronmal R">RA Kronmal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hershenson, Mb" uniqKey="Hershenson M">MB Hershenson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wark, Pa" uniqKey="Wark P">PA Wark</name></author><author><name sortKey="Tooze, M" uniqKey="Tooze M">M Tooze</name></author><author><name sortKey="Powell, H" uniqKey="Powell H">H Powell</name></author><author><name sortKey="Parsons, K" uniqKey="Parsons K">K Parsons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dhariwal, J" uniqKey="Dhariwal J">J Dhariwal</name></author><author><name sortKey="Edwards, Mr" uniqKey="Edwards M">MR Edwards</name></author><author><name sortKey="Johnston, Sl" uniqKey="Johnston S">SL Johnston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahanchian, H" uniqKey="Ahanchian H">H Ahanchian</name></author><author><name sortKey="Jones, Cm" uniqKey="Jones C">CM Jones</name></author><author><name sortKey="Chen, Ys" uniqKey="Chen Y">YS Chen</name></author><author><name sortKey="Sly, Pd" uniqKey="Sly P">PD Sly</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Koenighofer, Martin" sort="Koenighofer, Martin" uniqKey="Koenighofer M" first="Martin" last="Koenighofer">Martin Koenighofer</name></region><name sortKey="Bodenteich, Angelika" sort="Bodenteich, Angelika" uniqKey="Bodenteich A" first="Angelika" last="Bodenteich">Angelika Bodenteich</name><name sortKey="Fazekas, Tamas" sort="Fazekas, Tamas" uniqKey="Fazekas T" first="Tamás" last="Fazekas">Tamás Fazekas</name><name sortKey="Grassauer, Andreas" sort="Grassauer, Andreas" uniqKey="Grassauer A" first="Andreas" last="Grassauer">Andreas Grassauer</name><name sortKey="Lion, Thomas" sort="Lion, Thomas" uniqKey="Lion T" first="Thomas" last="Lion">Thomas Lion</name><name sortKey="Mueller, Christian A" sort="Mueller, Christian A" uniqKey="Mueller C" first="Christian A" last="Mueller">Christian A. Mueller</name><name sortKey="Prieschl Grassauer, Eva" sort="Prieschl Grassauer, Eva" uniqKey="Prieschl Grassauer E" first="Eva" last="Prieschl-Grassauer">Eva Prieschl-Grassauer</name><name sortKey="Unger, Hermann" sort="Unger, Hermann" uniqKey="Unger H" first="Hermann" last="Unger">Hermann Unger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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